Recent research has unequivocally shown that bioidentical hormones – when administered at the proper dosages – offer health benefits that far outweigh negative side-effects for most patients. However, too much of anything is never a good thing – and hormones are no exception. That is why the most conservative dosing possible is ideal – precisely replacing missing essential hormones without over-dosing – to avoid unwanted side-effects.
SottoPelle® pellet trained physicians no longer have to ‘guess’ or ‘estimate’ the lowest effect dose, thanks to the proprietary Dosaggio® online dosing application. Dosaggio® allows physicians to input a minimal set of relevant patient information and receive a conservative, precise, and individualized dose.
The Dosaggio® proprietary algorithm and on-screen clinical guidance enable physicians to prescribe the most conservative hormone therapy dose that is still effective in alleviating patient symptoms and optimizing patient health. This conservative hormone therapy dosing makes the SottoPelle® Method pellet administration the safest form of long-term testosterone replacement therapy and long-term treatment of perimenopause and menopause symptoms.

Subcutaneous pellets are the best choice when it comes to allowing a steady delivery of hormones. Hormone pellets are tiny implants, placed under the skin, that continuously release small, physiologic doses of hormones – just like the body does – consistently and constantly, as the patient needs them.
The pellet implants are made up of hormones (such as estrogen and testosterone) that are pressed or fused into very small, solid cylinders that are smaller than a grain of rice.  Once inserted under the skin, they deliver hormones for up to three months in women and up to six months in men.
Pellets are a superior method of hormone replacement deliver because they avoid the roller coaster “up and down” hormone “surges” that occur throughout the day with once-daily pills that wear off over 24 hours. Pellets also eliminate the delivery inconsistences that can occur when patients forget to take pills, or take them at irregular or incorrect intervals.