Hormones,  The Brain and Mental Health

“Heal Traumatic Brain Injury with Bioidentical Hormones”

Compiled by Michael Downey

As seen in Life Extension, Feb. 2015

Traumatic brain injury afflicts nearly 1.7 million Americans annually and causes devastating cognitive, emotional, and physical deficits.

Standard therapies frequently fail to provide significant recovery after the acute phase, and chronic symptoms can linger over a lifetime. Many patients are unable to fully re-enter society.

Innovative physicians are discovering that brain trauma can trigger deficiencies in certain hormones. When these hormones are restored using precise bioidentical therapy, a reversal of functional deficits associated with traumatic brain injury has been shown.

Beyond brain injuries, accumulating evidence suggests that—as rates of dementia and Alzheimer’s disease continue to explode—replenishing these same hormones may also help inhibit these degenerative brain diseases.

… And just as Dr. Tutera has shown that TBI symptoms can be treated and possibly reversed with sex hormones, the same hormones have been shown to reduce the risk of neurodegenerative diseases such as Alzheimer’s disease.

“Hormones and Happiness: An Insight into Our Brain Chemistry”

by Catherine J. Rourke

As seen in USA Today, Aug. 24, 2023

Neurobiology may sound complex, but boosting your brainpower is simple with SottoPelle® science.

“While this represents time-revered endocrinology and isn’t rocket science,” said Tutera, “BHRT offers a solution backed by studies in the prevention of serious maladies to offset the development of major diseases.”

According to Dr. Tutera, “This is the only safe, effective approach to eliminating the root of all disease and physical dysfunction by restoring hormonal balance, normal neurotransmitter processes and normal physiology of the body. It’s the best preventative antidote in modern medicine to alleviate the devastating illnesses and often fatal diseases caused by stress.”
As pioneers bringing pellet therapy back into the mainstream with precision dosing, SottoPelle® paved the way decades ago as the visionary industry leader for pellet practices across America.

Today, Dr. Tutera’s wife CarolAnn continues his legacy as president of SottoPelle®, now celebrating 30 years helping more than 250,000 patients worldwide enjoy happier, healthier lives.

“Harmonize Your Hormones for Health and Happiness”

by Karen Sheedy
Written in partnership with Catherine J. Rourke

As seen on Woman’s World , Nov. 13, 2023

Feeling frazzled, fatigued, funky and foggy-headed? Do you keep misplacing those car keys or spacing out names and numbers? Maybe you’re constantly down in the dumps.

As women age and experience menopause, they undergo dramatic changes in their bodies and brains, from memory loss, mood swings and insomnia to fluctuations in appetite, weight and stress.

The World Health Organization estimates that many of the 50 million women in the U.S. over age 51 face cognitive decline and related mental conditions such as Alzheimer’s, dementia and depression.

According to a 2023 Columbia University Irving Medical Center report, the spike in cognitive disorders for women over age 45 remains a growing health concern, with women representing 65 percent of Alzheimer’s patients.

The good news: there are steps you can take to cut your risk and stay happy and healthy at any age. And it starts with your hormones.

“How Testosterone Helps Boost Your Biceps And Your Brain”

by Catherine J. Rourke

As seen in Maxim, Oct. 14, 2024

Testosterone fuels the brain, influencing the neurotransmitters regulating your memory, mood, motor control, behavior and cognitive functions. Research indicates it has been used to treat osteoporosis, metabolic syndrome and cholesterol. T therapy may help prevent Alzheimer’s and other neurodegenerative diseases. 

As SottoPelle’s CEO, CarolAnn Tutera is the original female industry leader, continuing what she and Dr. Tutera started in the 1990s. “We’re working with ex-NFL players and veterans and excited about the progress they’re making,” she said. “We support everyone on their journey and have so many success stories.”

Advances in TRT therapy show it’s helping men stay sharp, strong and energized. A 2023 Harvard Health study cites the cardiovascular safety of TRT in preventing strokes and heart attacks. A recent meta-analysis of 35 clinical studies found TRT restored normal T levels to enhance men’s strength, brainpower and vitality without cardiovascular risks.

SottoPelle is committed to helping athletes, veterans, and anyone with head injuries or low T to regain their muscle and mojo.

“Boost Your Brain with Bioidentical Hormone Pellet Therapy”

by Catherine J. Rourke

As seen in Medical Daily, Nov. 13, 2025

Most people associate the sex hormones with puberty and reproduction. But estrogen, testosterone, and progesterone serve a much greater purpose in human health. 

Numerous studies demonstrate how the sex hormones act like a master switch for every organ and tissue of the body, regulating cognitive function, mood, sleep, and all the neurotransmitters. In fact, brain health hinges completely on hormonal balance.

One visionary medical team already connected the dots over 30 years ago, pioneering a safe, effective method for body and brain health. CarolAnn Tutera, president and CEO of SottoPelle®/Tutera Medical®, co-founded the company with her late husband, Dr. Gino Tutera, a medical pioneer renowned for his groundbreaking innovations using bioidentical hormone pellets.

Backed by 87 years of scientific research and slipped under the skin, subcutaneous pellets demonstrate the greatest efficacy in penetrating the blood-brain barrier for consistent hormone distribution.

“Improve your brain health by balancing hormones”

An Interview with
Steve Nunn, MPAS, PA-C, DFAAPA

Oct. 30, 2023

Sonoran Living. ABC 15 Arizona

Neurobiology may sound complex, but boosting your brain health is simple with SottoPelle®. Scientific research shows that hormones set the stage in motion for every function of the body and brain. Hormones trigger the release of chemical messengers that signal every cell to do its physical and mental job.

BHRT pellets release a consistent supply of plant-based hormones to the brain receptors, so every synapse, neurotransmitter and mitochondria receives the correct amount exactly when it is needed on a 24-7 basis for balanced physiology. Neuroscientists and medical researchers are now confirming what Dr. Tutera discovered over a decade ago: the intricate connection between hormones and brain health. Studies show that BHRT pellets not only enhance mood and cognitive function but also regulate the brain’s neurotransmitters.